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Memantine Treatment in Patients with Moderate to Severe Alzheimer Disease Already Receiving Donepezil, A Randomized Controlled Trial
JAMA 291:317-324, Tariot,P.N.,et al, 2004
See this aricle in Pubmed

Article Abstract
In patients with moderate to severe AD receiving stable doses of donepezil, memantine resulted in significantly better outcomes than placebo on measures of cognition, activities of daily living, global outcome, and behavior and was well tolerated. These results, together with previous studies, suggest that memantine represents a new approach for the treatment of patients with moderate to severe AD.
 
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Alzheimer's disease
Alzheimer's disease,treatment of
dementia,treatment of
donepezil
memantine
NMDA antagonists
treatment of neurologic disorder

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